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  "Description": "The ordered panel methodology (Zezulinski et al 2025\n<doi:10.1159/000545366>) provides a structured framework for\nidentifying and organizing sets of biomarkers, such as genetic\nvariants, that distinguish between positive and negative\nsubjects in a study when only a training cohort is available.\nThis approach is particularly useful in situations where an\nindependent validation cohort does not yet exist, rendering\nconventional performance metrics such as the receiver operating\ncharacteristic (ROC) curve and area under the ROC curve (AUC)\ninappropriate or potentially misleading. The methodology\nemphasizes transparent construction and evaluation of ordered\nsignatures of biomarkers, allowing investigators to examine\noperating characteristics without establishing predictive\nperformance.",
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